This offering is intended to be more of a discussion with faculty and any interested trainees in how to do science more efficiently. Cuts have recently been made at the NIH and NSF, but no scientist would argue that the current system is perfect. What regulatory architectures could be improved? Are there better ways to monitor compliance with required rules? What superstructures (bigger units than individual universities or NIH institutes) might serve the greater good? And what concrete steps should we be taking to make sure scientists are engaged in the process rather than just having to live with the (possibly bad) outcomes?